Yerlikaya, EmrahKarageçili, HasanKaya, Mustafa Oğuzhan2024-12-242024-12-2420202147-0634https://doi.org/10.5455/medscience.2019.04.049https://search.trdizin.gov.tr/tr/yayin/detay/367495https://hdl.handle.net/20.500.12604/5103Thalassemia is the most frequently seen monogenetic disorders around the world that is inherited as a recessive single-gene disease, resulting from mutations in ?-or?-globin gene clusters. In this study Beta Thalassemia Intermedia, Beta Thalassemia Minor, Sickle Cell Disease patients and the healthy control individuals both incidence and serum parameters were examined and analyzed retrospectively between 2015-2017 from Public Health information system. Beta Thalassemia Intermedia, BetaThalassemia Major, Beta Thalassemia Minor and Sickle Cell Disease patient groups incidences were evaluated on the basis of their HPLC analysis. Patients and controlgroups serum parameters levels were analyzed from their autoanalyzer results. These serum biochemical tests datas were controlled and taken from Siirt Public HealthCentre information system. In each year, there were recorded approximately 12 Beta Talassemia patients, 2 Beta Thallassemia Major patients, 340 Beta ThalassemiaMinor patients and 33 Sickle Cell Disease patients.Beta Thalassemia Intermedia patients serum parameters levels were compared with Beta Thalassemia Minor Patientsserum parameters and control group serum levels. There were seen statisticaly significant difference between Beta Thalassemia Intermedia patient’s serum ast, albumin,creatine, amylase, phosphor, iron, iron binding capacity, total protein, sodium, bilirubin direct, bilirubin total, LDH level and control serum parameters levels, p<0.05. Butthere were not seen statistically significant differences between Beta Thalassemia Minor patients serum levels and control serum levels. Studies like this should be donenationwide, in each city to determine the current state of abnormal hemoglobinopathies in Turkey. Thus, a broader, comprehensive national screening program is needed.eninfo:eu-repo/semantics/openAccessGenel ve Dahili Tıp,HematolojiArticle9370871336749510.5455/medscience.2019.04.049