Kaya, Mustafa OguzhanGulec, OzcanArslan, Mustafa2024-12-242024-12-2420181018-46191610-2304https://hdl.handle.net/20.500.12604/8105In this study, new bisoxadiazole substituted sulfonamide compounds were synthesized and in vitro inhibition effects of the compouds on purified human serum paraoxonase 1 (PON I) were investigated by using the method of Gan et al. The results showed that all the synthesized compounds inhibited the paraoxonase 1 enzyme activity. The compounds 6d and 6e were found to be most active compounds (IC50=26.5 mu M and 28.6 mu M) for PON1, respectively.eninfo:eu-repo/semantics/closedAccessParaoxonasebisoxadiazolesulfonamideantioxidant activityinhibitionArticle275A33513358Q4WOS:000436522400016