Emran, Mohammed Y.El-Safty, Sherif A.Elmarakbi, AhmedReda, AbduallahEl Sabagh, AymanShenashen, Mohamed A.2024-12-242024-12-2420222196-7350https://doi.org/10.1002/admi.202101473https://hdl.handle.net/20.500.12604/5836Chipset nanosensor design and fabrication are important for healthcare research and development. Herein, a functionalized chipset nanosensor is designed to monitor neurotransmitters (i.e., epinephrine (EP)) in human fluids. An interdigitated electrode array (IDA) is functionalized by N-doped carbon nanobud (N-CNB) and N-doped carbon nanostructure (N-CNS). The surface morphology of N-CNB shows the formation of nanotubular-like branches on sheets and micrometer-size tubes. The N-CNS design consists of the formation of aggregated sheets and particles in nanometer size. The irregular shape formation provides surface heterogeneity and numerous free spaces between the stacked nanostructures. N-atoms ascertain highly active N-CNS with multifunctional active centers, electron-rich charged surface, and short distance pathway. The N-CNB/IDA exhibits the best performance for EP signaling with high sensitivity and selectivity. The N-CNB/IDA sensing performance for EP detection indicates the successful design of a highly selective and sensitive assay with low detection limit of 0.011 x 10(-6) m and a broad linear range of 0.5 x 10(-6) to 3 x 10(-6) m. The N-CNB/IDA exhibits a high degree of accuracy and reproducibility with RSD of 2.7% and 3.9%, respectively. Therefore, the chipset nanosensor of N-CNB/IDA can be used for on-site monitoring of EP in human serum samples and further used in daily monitoring of neuronal disorders.eninfo:eu-repo/semantics/closedAccessadvanced nanocarbon materialselectrochemical sensorsbiosensorsfunctionalized electrodesnitrogen-doped carbon-based materialsportable nanosensorssensitive and selective epinephrine assayArticle91Q2WOS:000721431100001Q12-s2.0-8511967837210.1002/admi.202101473