Cengiz, Mustafa2024-12-242024-12-2420182147-16302146-586Xhttps://search.trdizin.gov.tr/tr/yayin/detay/292006https://hdl.handle.net/20.500.12604/5434Silymarin (Sm) is known for its anti-oxidative, anti-inflammatory, and antimitoticactivities against a broad range of cancers, such as prostate, colon, ovarian, skinand lung cancer. This study targets to determine the protective effects of Sm on lungdamage in the mice exposed to D-galactosamine (D-GaIN)/tumour necrosis factor alpha(TNF-?). For this purpose, three groups of Balb/c mice were used. The study groupswere given saline (0.5 mL), D-GalN/TNF-a, and D-GaIN/TNF-? plus Sm, respectively.Our biochemistry, apoptotic markers and light microscopic findings offer that Sm cannoticeably diminish D-GaIN/TNF?-induced pulmonary toxicity. In conclusion, Smimproves degenerative alterations in injured lung owing to D-GalN/TNF-a. This caringeffect might be thanks to the capability of Sm to keep oxidant–antioxidant stability.eninfo:eu-repo/semantics/openAccessTıbbi Araştırmalar Deneysel,Solunum Sistemi,Onkoloji,Biyokimya ve Moleküler BiyolojiArticle814252292006