Firidin, Mustafa NevzatAkyuz, Mehmet Emin2024-12-242024-12-2420221899-52762451-2680https://doi.org/10.17219/acem/149336https://hdl.handle.net/20.500.12604/7502Background. The inflammatory index can be useful for neurosurgeons to understand and grade pain in degenerated intervertebral disc (DIVD). Objectives. The study focused on the value of the platelet-to-lymphocyte ratio (PLR), neutrophil-tolymphocyte ratio (NLR) and the inflammatory multiple indices (MIs), and aimed to compare its efficiency with the preoperative and postoperative pain scale and scoring algorithms. Materials and methods. A total of 88 DIVD patients were included in this retrospective clinical cohort study. Visual Analogue Scale Back (VASB) and Visual Analogue Scale Leg (VASL), Oswestry Disability Index (ODI), Roland-Morris Disability Questionnaire (RMDQ), and walking distance (WD) were used to assess pain. The multiple index (MI) was calculated as MI-1 = PLR x C-reactive protein (CRP) and MI-2 = NLR x CRP. Results. Comparing the MI with ODI, no correlation was found in preoperative values, while a positive correlation (MI-1: r = 0.398, p < 0.001; MI-2: r = 0.285; p = 0.007) was found between the postoperative measurements. A significant correlation was found for VASB and both MI-1 (preoperative: r = 0.373, p = 0.001; postoperative: r = 0.232, p = 0.041) and MI-2 (preoperative: r = 0.388, p < 0.001; postoperative: r = 0.206, p = 0.044). The MI-1 index showed 71.4% sensitivity and 73.3% specificity, while the MI-2 index exhibited 78.6% sensitivity and 68.9% specificity. Conclusions. MI-1 and MI-2 showed a positive correlation with pre- and post- operative VASB score and had strong potential to predict postoperative pain in DIVD. They are easy-to-use, noninvasive and low-cost indices; therefore, our results are promising for routine application.eninfo:eu-repo/semantics/openAccesspain scoringdegenerated intervertebral discinflammation indexArticle319947952Q4WOS:000798778200001Q12-s2.0-851393745493554320010.17219/acem/149336