Demirhan, HulyaArslan, MustafaKaya, Mustafa OguzhanKaya, YesimGencer, NahitArslan, Oktay2024-12-242024-12-2420141857-55521857-5625https://hdl.handle.net/20.500.12604/8129In this study, 9-benzylidene-9H-fluorene-substituted urea (5a-p) and thiourea derivatives (5q-v) were synthesized and their inhibitory effects on the activity of human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II were purified from human erythrocytes using a Sepharose 4B-L-tyrosine-sulphanilamide affinity column. All the synthesized compounds inhibited the activity of the hCA I and II isoenzymes. Among the synthesized compounds, 5f was found to be the most active (IC50 = 21.4 mu M) for inhibition of hCA I and 5s was the most active (IC50 = 25.3 mu M) for inhibition of hCA II.eninfo:eu-repo/semantics/openAccess9-benzylidene-9H-fluoreneureathioureacarbonic anhydraseinhibitionArticle332Q4WOS:000345285100002