Erarpat, SezinBodur, SuleymanAyyildiz, Merve FiratGunkara, Omer TahirErulas, FatihChormey, Dotse SelaliTurak, Fatma2024-12-242024-12-2420200269-38791099-0801https://doi.org/10.1002/bmc.4915https://hdl.handle.net/20.500.12604/5847This work presents a sensitive and rapid analytical method for the determination of oxcarbazepine in human plasma and urine samples. A vortex-assisted switchable hydrophilicity solvent-based liquid phase microextraction (VA-SHS-LPME) was used to preconcentrate oxcarbazepine from the samples before the determination by gas chromatography mass spectrometry. The switchable hydrophilicity solvent was synthesized by protonatingN,N-dimethylbenzylamine with carbon dioxide to make it totally miscible with an equivalent volume of water. Parameters of the VA-SHS-LPME method including volume of switchable hydrophilicity solvent, concentration/volume of sodium hydroxide and vortex period were systematically optimized. Under the optimum conditions, good linearity ranging from 27.03 to 353.47 mu g/kg was obtained for the analyte. Limit of detection and quantitation values were found to be 6.2 and 21 mu g/kg (mass base), respectively. The relative standard deviation was calculated as 6.9% for six replicate measurements of the lowest concentration of the calibration plot. Satisfactory recovery results were calculated in the range of 97-100% for human plasma and urine samples spiked at five different concentrations.eninfo:eu-repo/semantics/closedAccessgas chromatography-mass spectrometryhuman plasmaoxcarbazepineswitchable hydrophilicity solventurineArticle3410Q4WOS:000548918900001Q32-s2.0-850871523063252964710.1002/bmc.4915