Karagecili, HasanYilmaz, Mustafa AbdullahAlwasel, Saleh H.Arik, MustafaGulcin, Ilhami2024-12-242024-12-2420231307-6167https://doi.org/10.25135/rnp.410.2305.2787https://hdl.handle.net/20.500.12604/7688Pistacia species containing turpentine which has protective effects and used as a medicine against diabetes, and infections for a long time. To interpret the antioxidant capacities of turpentine from Pistacia vera L. cv. Siirt, 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS(center dot+)) and 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH center dot), Fe3+- 2,4,6-tris(2-pyridyl)-S-triazine (TPTZ) and Cu2+ reducing ability were studied and compared to reference antioxidants of BHT, BHA, alpha-Tocopherol, and Trolox. The IC50 of turpentine for ABTS(center dot+) and DPPH center dot scavenging capacities were determined to be lower than reference antioxidant standards as 231.1 mu g/mL and 346.6 mu g/mL, consequently. The total flavonoid and phenolic contents in turpentine were measured as 12.5 mg GAE/g and 38.852 mg QE/g, respectively. For determination of antidiabetic, anti-Alzheimer, and antiglaucoma effects of turpentine, acetylcholinesterase (AChE), alpha-glycosidase and carbonic anhydrase II (hCA II) enzymes inhibition abilities of turpentine were performed. The IC50 values of turpentine extract against alpha-glycosidase, hCA II, and AChE enzymes were found as 2.04, 3.59 and 14.6 mu g/mL, respectively. The quantity of protocatechuic acid and naringenin were determined using LC-MS/MS against 53 standards. The results clearly demonstrated polyphenolics in P. vera L. cv. Siirt turpentine is a natural product has potential usage in amelioration of glaucoma, AD, diabetes, and epilepsy.eninfo:eu-repo/semantics/openAccessPhenolic compoundsturpentineantioxidanta-glycosidaseacetylcholinesterasecarbonic anhydraseComprehensively Revealing the Profile of Pistacia vera L. cv. Siirt Turpentine - Antioxidant, Antidiabetic, Anti-Alzheimer, and Antiglaucoma EffectsArticle175918937Q3WOS:001258136200005Q22-s2.0-8517152322810.25135/rnp.410.2305.2787