Gursul, CebrailAkdemir, Fazile Nur EkinciAkkoyun, TuranCan, IsmailGul, MustafaGulcin, Ilhami2024-12-242024-12-2420161475-63661475-6374https://doi.org/10.3109/14756366.2016.1167050https://hdl.handle.net/20.500.12604/7758This study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p<0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p<0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p<0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application.eninfo:eu-repo/semantics/openAccessAntioxidant enzymesischemia/reperfusion injuryNaringinreactive oxygen speciesskeletal muscleArticle315661Q1WOS:000389344900007Q12-s2.0-849640567572705245210.3109/14756366.2016.1167050